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m a p s v o l u m e X I n u m b e r 1 s p r i n g 2 0 0 1
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Fiscal Year 1999-2000 June 1, 1999 - May 31, 2000
Jump to: Expenses for Research / Expenses for Educational Purposes / Organizational Expenses / Staff Expenses / Office Expenses
Normally, MAPS publishes a detailed report of its annual income and expenditures in the calendar year's final issue of the Bulletin. Last December, in a departure from tradition, MAPS published a special issue of the Bulletin with the theme of Psychedelics and Creativity. We wanted to keep the special issue focused on that topic and decided to publish the annual financial report for FY 99-00 in the first issue of this year. The increasingly heavy workload that MAPS' staff has undertaken has affected the timeliness of this issue of the Bulletin, and therefore of this annual financial report. MAPS' staff time has been devoted both to a growing number of substantive projects, and to an increasing amount of time spent communicating with members, the public, the media and governmental authorities. Subsequent issues of the Bulletin should resume being produced on our regular quarterly schedule.
Staff Time Spent on Media Relations I feel that its important to allocate substantial time to speak to the media in order to help journalists present the public with a more balanced picture of MDMA. Fortunately, Dr. Charles Grob, an MDMA researcher at Harbor UCLA Medical Center who works closely with MAPS, is also willing to take time to talk with journalists. Public support for the medical uses of MDMA and other psychedelics is important to try to generate in order to create a supportive regulatory climate for MDMA research. In a related context, public support for the medical uses of marijuana has resulted in FDA-approved and NIH-funded research that otherwise might not have been approved or funded. Yet no matter how much time Dr. Grob and I and other allied experts talk with reporters, the opportunities we have to discuss MDMA's therapeutic potential and to put forward reasonable risk estimates are only a drop in the bucket compared to the tens of millions of dollars of anti-ecstasy ads and other forms of "education" the federal government is funding. Fortunately, the websites that MAPS has helped support, Erowid, DanceSafe, and Alchemind, and also the MAPS website, have attracted tremendous attention and have substantial credibility. Media presentations about MDMA now frequently include at least some mention of MDMA's therapeutic potential and often question the dire pronouncements of some government officials stating that even one dose of MDMA will result in serious and permanent brain damage. In addition to the time it takes to respond to media, MAPS' wider visibility has resulted in a flood of e-mail. This is, unfortunately, all too common a challenge these days. As many people have experienced, it's difficult to keep one's head above the rising waters of e-mail. Despite the struggles, it's a privilege and a joy to work at MAPS. The following report will explain in detail how MAPS allocated its financial resources in FY 1999-2000. From this report, MAPS members can see MAPS' strategy in action as well as ascertain our priorities. Comments of all types are invited.
MAPS Financial Overview
Educational Overview
MDMA Overview In FY 99-00, MAPS' most expensive and top priority effort has been the sponsoring of a mammoth effort to review all the scientific literature on MDMA published in peer-reviewed journals, for submission to the FDA and to other regulatory agencies around the world. Matt Baggott has been leading the literature review team, with excellent full-time assistance from Ilsa Jerome in Boston and part-time assistance from R. Stuart and Michael Bauer in San Francisco. Associated with the MDMA literature review project has been an MDMA bibliography project, under the direction of Earth and Fire at Erowid (see page 19 for an update on this project.) We are creating an electronic database listing every study ever published, with digitized PDF copies to permit regulatory authorities, researchers and students to access the basic data upon which our risk assessments are based. Finally, MAPS has been coordinating the development of an MDMA-assisted psychotherapy protocol for submission to the FDA. The study, under the direction of Dr. Michael Mithoefer, Dr. Kathleen Brady, Annie Mithoefer R.N., and Mark Wagner, Ph.D., is designed as a preliminary pilot study. The study will gather basic information about the safety and efficacy of the use of two MDMA-assisted psychotherapy sessions in patients suffering from chronic Post-Traumatic Stress Disorder (PTSD). If approved, and I believe that some variation of what we submit to the FDA will be approved, the study will be the first scientific investigation of the use of MDMA in a patient population since MDMA was criminalized in 1985. The study will mark the start of MAPS' $5 million, 5-year pharmaceutical drug development plan to transform MDMA into an FDA-approved prescription medicine. A Clinical Plan explaining the assumptions behind this estimate can be found on the MAPS website at: /research/mdmaplan.html.
Ketamine Overview
Psilocybin Overview
Medical Marijuana Overview MAPS, in association with CANORML, planned in FY 99-00 and initiated in FY 00-01 a study of the constituents of marijuana "smoke", or more accurately marijuana "vapor." The basic concept is that vaporizers heat the marijuana plant but don't burn it, in a sense boiling out the cannabinoids and other materials. Due to the lack of combustion, the vaporizer may be a "safer" delivery system. (see page 20 for an update on this study.)
Staff Overview The new team in Sarasota is composed of two full-time staff members, Maggie Hall and Nicole Tavernier. They work out of Arcturus, the home I designed and built at age 21, in the hopes that construction would help me get grounded after a series of difficult psychedelic experiences. Also in Sarasota is Mercedes Paulino, who works part-time out of her home, running the MAPS website and other information-related tasks. I'm still located in Boston.
Detailed Income Report Income came primarily from about 1900 members, roughly the same number of members as last year. (MAPS' goal is to increase membership to at least 2,500.) Nineteen individuals and one corporation gave $1,000 or more, for a total of $214,365, while nine foundations gave $155,935. The remaining $184,992 came from the rest of the membership, book sales, and income on investments. The nine foundations that donated to MAPS in FY 99-00 include the Promind Foundation ($93,286), Smart Family Foundation ($22,000), Place Foundation ($20,000), Low Wood Foundation ($7,000), Angelica Foundation ($4,000), Jewish Communal Fund ($3,000), Zimmer Family Foundation ($2,650), Tarcher Family Foundation ($2,500), and the Odyssey Foundation ($1,500). The individuals or corporations that donated $1,000 or more include John Gilmore ($78,480), Robert Barnhart ($26,000), Ray Joseph Greenwell ($25,000), Tim Butcher ($24,400), Melisa Richardson ($10,000), Paul Phillips ($10,000), Anonymous ($7,000), Betsy Gordon ($5,273), Andrew Stone ($5,086), Ivan Kruglak ($5,000), Jack Adams ($3,000), Richard Wolfe ($3,000), Marsha Rosenbaum ($2,500), Julie Holland, who donated to MAPS' Holland Fund for Therapeutic MDMA Research and to which she invites others to contribute ($2,125), Anonymous ($2,000), Mark Williams ($1,500), Anonymous ($1,000), Anonymous ($1,000), Jamie Williams ($1,000), and Perfect Fungi Europe ($1,000).
Expenditures
Balance/Net Assets Of MAPS' $379,423 in net assets at the close of FY 99-00, $40,000 is not available for use but represents the net present value of MAPS' remainder interest in a home that MAPS will receive in its entirety in forty to fifty years. Roughly $200,000 will be needed for the MDMA/PTSD research project MAPS is seeking to initiate in the United States, should it be approved (which I expect it will be). About $100,000 will be needed for the medical marijuana production facility MAPS is trying to establish should lightening strike and DEA permission is actually granted for this project. As a matter of fiscal strategy, MAPS will seek to raise new funds for all projects in development that do become approved. If new funds can be obtained for approved projects, MAPS can retain some net assets along with the ability to guarantee funding to additional pioneering studies in the development phase, should they also become approved. Of course, MAPS can only pledge to fund projects whose cost is lower than MAPS' unallocated assets. The major way I look at MAPS' net assets is in comparison with the estimated cost of achieving MAPS' primary goal, that being to obtain FDA approval for the medical use of MDMA as an adjunct to psychotherapy. Based on what I believe are reasonable financial assumptions, I've estimated that it will cost $5 million and take 5 years to conduct sufficient research to demonstrate to the satisfaction of the FDA the safety and efficacy of MDMA-assisted psychotherapy in the treatment of patients suffering from Post-Traumatic Stress Disorder (PTSD). (see the Clinical Plan at: /research/mdmaplan.html.) From this perspective, MAPS' current net assets are sufficient only for the first steps of this clinical plan. However, I've always believed, and so far have had that belief confirmed, that funding can and will be obtained for all the successive steps in the research process, once the protocols are fully approved and ready to be implemented.
Request for Feedback
MDMA-Related Projects MAPS allocated $19,923 in FY 99-00 for researchers and consultants to begin the process of reviewing all the scientific literature on MDMA. When MAPS initiated the review, it was intended to be used first as support for a protocol to be submitted to FDA by Charles Grob, M.D., Harbor-UCLA Medical Center. The protocol will be designed to evaluate the use of MDMA-assisted psychotherapy in the treatment of depression in end-stage cancer patients. Dr. Grob's protocol will likely be submitted to the FDA in Fall 2001. Promind Foundation made substantial contributions to the MDMA literature review project. As it turns out, the literature review will first be submitted to the FDA in May 2001 in support of a protocol designed to study the use of MDMA-assisted psychotherapy in the treatment of patients suffering from chronic PTSD. This study will be conducted in Charleston, South Carolina, with Dr. Michael Mithoefer, a psychiatrist, and Annie Mithoefer, a registered nurse, working as the male/female co-therapist team. Dr. Mithoefer has been board certified in emergency medicine, internal medicine and psychiatry. Both Michael and Annie Mithoefer have studied under Dr. Stan Grof and are certified Holotropic Breathwork practitioners. Co-investigators are Dr. Kathleen Brady and Mark Wagner, Ph.D. This MDMA/PTSD protocol represents the culmination of almost two years of work conducted by MAPS-funded researchers. MAPS funded the assembling of a complete digitized bibliography of the entire scientific literature on MDMA published in peer-reviewed scientific journals (about 900 papers), the writing of a comprehensive review of the published data, as well as the latest unpublished data from on-going government-approved clinical trials with MDMA, the bringing together of an outstanding team of researchers to design the protocol, and the gathering of a group of experts to critique the proposed protocol design prior to submission to FDA. MAPS allocated $11,000 in FY 99-00 to Alex Gamma, Ph.D., for his work writing several scientific papers based on MDMA research he conducted at the University of Zurich under the direction of Dr. Franz Vollenweider. For more information on these papers, see the MAPS website list of completed MDMA projects. Promind Foundation donated $10,000 toward Dr. Gamma's project. MAPS allocated $14,000 for the analysis by a DEA-licensed lab of samples of Ecstasy pills sent in anonymously from around the country. It costs $100 to analyze each pill, but is free to the people who send in the pills. The purpose of the pill analysis research project was to determine what Ecstasy pills actually contained. This was undertaken as harm reduction research, with the results made public on the DanceSafe website. The study revealed that a substantial percentage of Ecstasy pills contained absolutely no MDMA and often contained potentially dangerous adulturants. For more details, see http://www.dancesafe.org/currentresults.html The costs of this program were funded by the Promind Foundation.
Psilocybin in the Treatment of Obsessive-Compulsive Disorder This study has not yet treated its first patient. In November 2000, FDA requested more analytical data from the DEA-licensed manufacturer of the psilocybin to ensure that the drug is safe for use in humans. In FY 00-01, MAPS paid $1,750 for this additional analytical data, which has satisfied the insatiable FDA. When the first patient is treated, it will mark the first time in over twenty-five years that psilocybin has been given to a patient in the context of an FDA-approved study. This research project is yet another example of the need for patience in seeking approval for psychedelic research. The protocol was approved by the FDA in September, 1998. The two and a half years since then have been focused solely on obtaining an FDA-approved supply of psilocybin. MAPS decided to have new supplies manufactured after it proved impossible to obtain any from the National Institue of Drug Abuse (NIDA) or the National Institute on Mental Health (NIMH).
Bastiaans LSD Follow-up
Marijuana in the Treatment of Migraines Marijuana is the only Schedule 1 drug for which NIDA has a monopoly on the supply that can be used in FDA-approved clinical trials. Unfortunately, NIDA is less than enthusiastic about facilitating research into the potential therapeutic benefits of smoking the marijuana plant. On May 21, 1999, NIDA and Health and Human Services (HHS) established a policy whereby research with marijuana became subjected to more reviews than any other drug in the United States. Research must now be approved, not only by the FDA and an IRB, but also by a special committee of the Public Health Service (PHS). This PHS committee rejected Dr. Russo's protocol even though all he and MAPS were seeking was the right to purchase low-quality marijuana at high prices from NIDA for an FDA-approved study. No government money was requested for the study. For the sorry history of the effort to research marijuana in the treatment of migraines, see /mmj/mjrusso.html MAPS, Dr. Russo and the Marijuana Policy Project (MPP) tried to make the proverbial lemonaide out of this lemon. On February 20, 2001, we submitted an Amicus Curiae brief to the U.S. Supreme Court in the Oakland Cannabis Buyer's Cooperative medical marijuana case (/mmj/maps-mppbrief.html). We have tried to turn our frustrating experience with NIDA to the advantage of medical marijuana patients by letting the U.S. Supreme Court know that for marijuana, the FDA drug development process is politically obstructed. The basic point of our brief is that these obstructions create a compelling case for the medical necessity defense for patients who run into conflict with the police over their use of marijuana as medicine. Dr. Russo has decided to abandon his struggle to conduct FDA-approved research into marijuana's therapeutic potential in treating migraine patients. Instead, he has designed a basic safety study to evaluate the health of those few patients remaining alive who legally receive marijuana from NIDA as part of the Compassionate Investigational New Drug (IND) program, which in 1992 was closed by HHS to any additional patients. MAPS has pledged $10,000 for this study. (see page 21 of this issue for more details about this study.)
Ketamine Research
Takiwasi Expenses for Educational Purposes
MAPS MDMA Conference, Dead Sea, Israel, August 1999 MAPS' MDMA conference was attended by at least one representative from every team in the world that had obtained governmental permission to administer MDMA to human volunteers in the context of clinical research. The purpose of this conference was twofold; to facilitate communication and collaboration between the world's MDMA researchers, and to educate representatives of the Israeli Ministry of Health as part of MAPS' efforts to start research in Israel into the use of MDMA in the treatment of Post-Traumatic Stress Disorder (PTSD). For more information on this conference, see /news-letters/v09n4/09402dob.html Due to the increased level of violence in the Middle East stemming from the failure of the peace talks, the need for new treatments for PTSD is greater than ever. However, MDMA psychotherapy research remains controversial in Israel. It now seems that the Israeli authorities are waiting until after the FDA approves MDMA psychotherapy research before permitting a MAPS-funded MDMA/PTSD study to take place in Israel. An April 2001 article on MDMA from the Israeli newspaper, Haaretz, which mentions MAPS' efforts to start MDMA/PTSD research in Israel, can be found on the MAPS website in the section on MAPS in the media.
DanceSafe DanceSafe's boldest harm reduction activity, which generated substantial media attention, was to pioneer the use of MDMA testing kits at raves, designed to determine whether pills sold as Ecstasy actually contained any MDMA. The test kits were used at raves by DanceSafe's local chapters, which were established around the country. DanceSafe also assumed responsibility for managing and funding the more sophisticated laboratory-based pill testing program that MAPS had initiated. Sylvia Thyssen, who had worked at MAPS since 1993, moved to San Francisco at the end of FY 99-00 in order to work full-time for DanceSafe, moving out of the MAPS frying pan (with its relatively conservative research agenda) into the DanceSafe fire (with its more controversial harm-reduction agenda). MAPS continued to act as DanceSafe's fiscal sponsor in FY 00-01. Among others, Ray Joseph Greenwell donated $25,000 for DanceSafe, John Gilmore donated $20,000, and Paul Phillips donated $10,000.
Erowid Through a not completely coincidental turn of events, the creators of Erowid (Earth and Fire Erowid) and I all went to college together at New College of the University of South Florida, that bastion of academic experimentation that coupled rigorous academic standards with a fundamental belief in the value of facilitating each student's exercise of his or her own intellectual curiosities.
Alchemind Promind Foundation donated $28,505 to MAPS for Alchemind in FY 99-00. ($18,505 of Promind's donation was not disbursed to Alchemind until FY 00-01.) MAPS continued to act as fiscal sponsor for Alchemind in FY 00-01.
Web-Based Psychedelic Bibliography - New Research Work on the web-based psychedelic bibliography was supported by a grant from Promind Foundation.
Albert Hofmann Foundation LSD/Psilocybin Bibliography A collection of nearly all of the scientific peer-reviewed published articles on LSD and psilocybin is in the possession of the Albert Hofmann Foundation. The bibliography project will expand substantially during FY 01-02 with the goal of creating a PDF file of each paper, linked to each bibliographic entry. A substantial number of volunteers will be needed to complete this project at an affordable cost. This project is being supported by the Promind Foundation. (For more information, see the article on page 19 in this Bulletin.)
DMT - The Spirit Molecule, by Dr. Rick Strassman
Ketamine: Dreams and Realities, by Dr. Karl Jansen
LSD Psychotherapy, by Dr. Stan Grof
The Secret Chief, by Myron Stolaroff,
Orenda Institute Conference - Hollyhock, British Columbia, Canada
Psychedelic Elders Conference
Ibogaine Conference
MAPS Forum
MAPS Bulletin I've come to the conclusion that hard-copy issues of the Bulletin are still important to MAPS' educational and community-building mission. The Bulletins act as a permanent physical record of MAPS' activities, of the scientific research papers that are presented within the Bulletin, and of topics of interest to the MAPS community. It's more pleasurable to read hard copy than a computer screen, and the Bulletin provides MAPS members with the opportunity to show something tangible to their friends who may wish to learn more about MAPS and its agenda. However, the use of the Bulletin to transmit information of a timely nature, or of an extremely detailed nature like a long protocol or literature review, is limited. This sort of information is more efficiently communicated through the MAPS website. I'd like to expand the use of the MAPS website for more timely and detailed content. I'd also like to expand the use of e-mail to send out occasional time-sensitive messages to MAPS members, so please consider sending your current e-mail address to the MAPS office at info@maps.org. MAPS is going to experiment with focusing the next two color cover Bulletins on themes that speak to broader topics than just MAPS' pharmaceutical drug development efforts, which seek primarily to move psychedelics and marijuana through the FDA drug review and approval process. These upcoming issues will be similar to the recent Psychedelics and Creativity issue which was enthusiatically received and is turning out to be the first MAPS Bulletin that we have ever reprinted. The two non-color cover issues will continue to focus on articles more directly related to MAPS' projects, research reviews, general updates, interviews, conference reports, book reviews, and other such content.
Postage
Copies
Phones
Internet
Books and Tapes
MAPS Ads and Membership Drive
Information
Staff Travel
Conference Fees
Professional Services
Salary, Benefits and Taxes Rick Doblin's salary remained at $30,000 in both FY 98-99 and FY 99-00, with no health care benefits in either year. Sylvia Thyssen's salary increased in FY 99-00 to $32,600, from $28,600, with full health care benefits. Carla Higdon's salary increased in FY 99-00 to $26,880, from $22,880. Both Sylvia Thyssen and Carla Higdon, though not Rick Doblin, also received payments into a retirement account set up by MAPS for their benefit. A total of $3,300 was placed into Carla's account, while a total of $5,220 was placed into Sylvia's account, reflecting her seniority at MAPS. As with most non-profit organizations, MAPS' salaries are lower than those for jobs in the private-sector with comparable skills and responsibilities. The lower salary is compensated for by the satisfaction of working on issues that have personal and social relevance. This wage disparity is also due to the fact that a large fraction of MAPS' income consists of restricted funds that go 100% to projects or other organizations, leaving less for organizational expenses than a quick glance at MAPS' FY 99-00 income of $555,292 would suggest. For FY 00-01, Rick Doblin's salary remained at $30,000, without health care benefits. Sylvia Thyssen moved to SF and started working for DanceSafe as of the end of FY 99-00. Carla Higdon received a raise from $26,880 to $28,224. The amount going into her retirement account increased from $3,300 to $4,740. Health care benefits stayed the same. Maggie Hall was hired as the third full-time staff member at a salary of $26,880, with retirement benefits of $1,260 and full health care benefits. Mercedes Paulino was hired several months into FY 00-01 as a part-time staff member whose responsibilities included being in charge of MAPS' website at a salary of $12.50 an hour, with full health-care benefits but no retirement contributions.
Office Supplies
Office Rent
Office Equipment
Computer Equipment
Fees, Bank and Regulatory Conclusion MAPS had a successful and active year in FY 99-00, with a mix of educational and research projects. In terms of clinical research, much of what took place in FY 99-00 was laying the groundwork for research projects still to be approved. Now that I have completed my dissertation, I feel a bit more wind in my sails. Simultaneously, the social breezes are shifting directions somewhat. With skill and patience, it's possible to create increasingly greater opportunities to advance MAPS' agenda. As the teamwork between MAPS' staff and our membership continues to develop and expand, MAPS becomes more effective. I'm reminded yet again of Theodore Hertzl's inspiring words, "If you will it, it is no dream." |
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