A Nov. 1, 2000 JAMA letter
reports on
the DanceSafe/MAPS pill testing program
(the letter says people paid for their own testing but that was a mistake.
MAPS paid for most of the testing of these pills).
For current pill analysis of Ecstasy see
DanceSafe's pill-testing page
Please visit MAPS' MDMA Research Page
MAPS MDMA Analysis Project
Rick Doblin
In February and March of 1996, people from around the United States and
England sent MDMA for analysis to a licensed testing facility. The purpose
of the study was to gather information about the quality of the MDMA being
sold on the underground market in the United States and England.
Information about the quality of MDMA is necessary in order to estimate
the dangers faced by users of illicitly manufactured and distributed MDMA
and to place reports of adverse effects in some context.
A total of 33 samples were tested, 22 from the United States, 10 from
England and 1 from South Africa. Quantitative and qualitative analyses
were conducted on all the samples. The total cost of the study was $3,520.
Nicholas Saunders, author of E for Ecstasy, Ecstasy and the Dance Culture
and the forthcoming Dance, Trance and Transformation, donated $1,650 to
MAPS for the study. An additional $1,100 was donated to MAPS for the study
from High Times Magazine. A total of $660 came from MAPS' general fund and
the remaining $110 was paid directly by a private individual.
Technological Limitations
The testing was conducted with a gas chromatograph-mass spectrometer
(GC/MS). The gas chromatograph separates the different components of the
sample. The mass spectrometer identifies the atomic composition of each of
the components. This data is then compared by a computer to a data base
of hundreds of known drugs and other compounds to see if there are any
matches. In this way, many of the ingredients in the samples can be
identified.
There are some limitations to the GC/MS technology. Certain inorganic and
some organic compounds may not volatilize and/or chromatograph and
therefore would not be detected. These compounds include baking soda, baby
powder and certain sugars that are sometimes used to dilute cocaine and
other drugs in powder form such as MDMA. There also may be many compounds
that can be detected by the GC/MS technology but are not contained in the
computer data base and therefore cannot be identified.
United States Samples
We were fortunate to obtain a rather good geographic distribution of the
22 samples from the United States. Five samples came from New York State,
of those 3 came from New York City and 2 from other parts of the state.
Three samples came from near Chicago, Illinois. One sample was from
Minneapolis, 1 from Eunice, Louisiana (near Baton Rouge), 1 from
Charlotte, North Carolina and 1 from Sarasota, Florida. Ten samples came
from California, of those 3 were from San Francisco and 7 were from the
Santa Barbara/Los Angeles area. Despite the fact that the samples were
from around the country, there is no way to determine if they comprise a
representative sample of the MDMA being sold in the United States.
Therefore, the results from this study can be used only to draw inferences
and not conclusions about the content of the pills and capsules being sold
as MDMA in the United States. Furthermore, according to Nicholas Saunders,
"you cannot be sure that any pill that looks similar to the ones
illustrated will have similar contents. When a pill earns a good
reputation, it is frequently exploited by dud lookalikes after a few
weeks, and the same press may be used for completely different
ingredients." Of the 22 samples from the United States, 17 were
tablets and 5 were capsules. Eight out of the 22 samples had no MDMA at
all. Interestingly, all the capsules contained MDMA while only about half
of the tablets did so. Of those samples that did contain MDMA, the highest
dose was 119 mg. The lowest was 45 mg. Of the 14 samples that contained
MDMA, the average dose was 79 mg. This average is significantly lower
than the standard dose sold before the criminalization of MDMA which was
in the range of 100-125 mg. Doses lower than 100 mg. are generally
considered to be below the level at which many people will feel the full
effects of MDMA.
Of the 14 samples that contained MDMA, only 1 also contained another
psychoactive compound identified by the GC/MS. That sample was a tablet
from New York State that contained MDMA and caffeine. In the remaining 13
samples, MDMA was 100% of only three of those samples, all capsules from
San Francisco. The other samples contained a range of percentages of other
ingredients that were not measured by the GC/MS technology. For example,
the capsule of MDMA from Santa Barbara was only 59% MDMA, the capsule from
Sarasota was 85% MDMA and the tablet from New York City was 25% MDMA.
While these unidentified ingredients could have been another psychoactive
ingredient or a byproduct of manufacturing, they were not cocaine, heroin,
barbiturates, benzodiazapines, tranquilizers, hypnotics, ketamine,
methamphetamine, amphetamine or any of several hundred other compounds.
Some of these unidentified ingredients were fillers or binding agents used
in the manufacture of the tablets. Whether these unidentified ingredients
are toxic cannot be determined. The common rumor that MDMA is frequently
cut with heroin was not substantiated.
Of the 8 samples that contained no MDMA, 2 contained the psychoactive drug
MDE (3,4-methylenedioxyethylamphetamine), a chemical cousin of MDMA that
generates an emotional reaction that is not quite as profound as that of
MDMA, and 1 contained an unidentified compound. The remaining 5 contained
various combinations of ingredients found in over-the-counter preparations
including dextromethorphan (an ingredient found in cough suppressants that
has an alcohol-like psychoactive effect especially in higher doses),
ephedrine / pseudoephedrine (a stimulant found in many plants,
over-the-counter medicines and Herbal Ecstacy and other similar
pseudo-MDMA products), phenylpropanolamine (a decongestant and mild
stimulant found in cold medicines), and glyceryl guaiacolate (a compound
that dries sinuses and is an expectorant). The ingredients in the samples
that did not contain MDMA raise some degree of concern since the
interaction of genuine MDMA and ephedrine / pseudoephedrine could provoke
a significant elevation in blood pressure. Such interactions could occur
if someone were to take two different samples at a time, one containing
genuine MDMA and the other containing ephedrine / pseudoephedrine. In one
case, a person who had taken 20 mg. of pseudoephedrine in the morning and
MDMA later in the day reported having transitory severe anginal chest
pain.
England and South Africa Samples
Just like the samples from the United States, the 10 samples from England
and the 1 sample from South Africa are not necessarily representative of
the MDMA being sold in those countries. Of the 10 samples from England,
five contained MDMA. Three of these 5 samples contained only MDMA, 1
contained a small amount of caffeine in addition to the MDMA and 1
contained some MDE in addition to the MDMA. The average dose of MDMA in
these five samples was 128 mg., substantially larger than the average dose
of the samples from the United States. The only psychoactive compound
detected in 3 samples was MDE. In 2 samples the only psychoactive compound
detected was caffeine. Thus, 8 out of 10 samples contained some MDMA or
MDE, two drugs with a somewhat similar subjective effect. The 1 sample
from South Africa contained only one psychoactive ingredient, MDMA, and a
very substantial dose of 138 mg.
Conclusion
All the capsules from the United States contained MDMA while only about
half the tablets did so. The samples with MDMA were likely to be weak,
averaging only 79 mg., well below the standard dose generally considered
to be in the range of 100-125 mg. The one capsule from England contained
caffeine and only half the tablets contained MDMA, averaging 128 mg. per
tablet. It seems that the doses of MDMA in the United States are lower
than those in England, perhaps a contributing factor in the virtual
absence of MDMA-related deaths in the United States. Four out of 10
samples from England contained MDE while only 2 samples out of 22 in the
United States contained MDE. Perhaps there are differential penalties
between MDMA and MDE in some countries in Europe, in the United States
both MDMA and MDE carry the same penalty. While there were no toxic
additives found in any of the samples, there were unidentified ingredients
in virtually all the samples. It is possible that all of these compounds
were benign fillers or binders of some sort used in the manufacturing of
the tablets or benign "cuts" used to expand the amounts of the
powder. However, the safety of MDMA tablets and capsules cannot be
determined with certainty. Nevertheless, the claims that MDMA is
frequently mixed with crushed glass, rat poison, heroin and other
dangerous substances has not been substantiated.
Location
|
Form
|
Markings
|
MDMA
|
How Much?
|
% MDMA
|
What Else?
|
Chicago
|
Tab
|
white
|
Yes
|
est. 45 mg
|
19%
|
unidentified
|
Chicago
|
Tab
|
white, scored, .7 cm
|
Yes
|
67 mg
|
59%
|
unidentified
|
Chicago
|
Tab
|
bluish, 1 cm
|
Yes
|
73 mg
|
21%
|
unidentified
|
New York
|
Tab
|
yellow, .8 cm
|
Yes
|
46 mg
|
16%
|
caf & unidentified
|
New York City
|
Cap
|
blue & clear
|
Yes
|
72 mg
|
79%
|
unidentified
|
New York City
|
Tab
|
white, scored, .8 cm
|
No
|
0 mg
|
0%
|
MDE & unidentified
|
New York City
|
Tab
|
white, scored, .8 cm
|
No
|
0 mg
|
0%
|
MDE & unidentified
|
New York City
|
Tab
|
Rolex crown, .6 cm
|
Yes
|
65 mg
|
25%
|
unidentified
|
Sarasota
|
Cap
|
clear
|
Yes
|
92 mg
|
85%
|
unidentified
|
Eunice, LA
|
Tab
|
white, scored, 1 cm
|
No
|
0 mg
|
0%
|
dex and phenyl
|
Minneapolis
|
Tab
|
white, scored, .9 cm
|
No
|
0 mg
|
0%
|
phenyl, eph, glyc
|
Charlotte
|
Tab
|
white, no markings, 1 cm
|
No
|
0 mg
|
0%
|
unidentified
|
San Francisco
|
Cap
|
clear
|
Yes
|
est. 72 mg
|
100%
|
nothing else
|
San Francisco
|
Cap
|
clear
|
Yes
|
112 mg
|
100%
|
nothing else
|
San Francisco
|
Cap
|
clear
|
Yes
|
119 mg
|
100%
|
unidentified
|
San Francisco
|
Cap
|
clear
|
Yes
|
73 mg
|
59%
|
unidentified
|
Santa Barbara
|
Tab
|
green, 1 cm
|
Yes
|
102 mg
|
29%
|
unidentified
|
Santa Barbara
|
Tab
|
white, scored, 1 cm
|
No
|
0 mg
|
0%
|
phenyl, eph, dex, glyc
|
Santa Barbara
|
Tab
|
yellow, speckled, scored, 1.3 cm
|
No
|
0 mg
|
0%
|
dex, eph, unidentified
|
Santa Barbara
|
Tab
|
solid yellow, 1.3 cm
|
No
|
0 mg
|
0%
|
dex, eph, unidentified
|
Santa Barbara
|
Tab
|
white, scored, .7 cm
|
Yes
|
92 mg
|
71%
|
unidentified
|
Santa Barbara
|
Tab
|
yellow, speckled, 1 cm
|
Yes
|
72 mg
|
18%
|
unidentified
|
England
|
Tab
|
pink, scored, .9 cm
|
No
|
0 mg
|
0%
|
caf, unidentified
|
England
|
Tab
|
white, Dove, .9 cm
|
Yes
|
111 mg
|
38%
|
unidentified
|
England
|
Tab
|
white, Dove, .9 cm
|
Yes
|
134 mg
|
41%
|
unidentified
|
England
|
Tab
|
white, Playboy, scored, .9 cm
|
Yes
|
159 mg
|
56%
|
MDE, unidentified
|
England
|
Tab
|
white, Playboy, scored, .9 cm
|
Yes
|
28 mg
|
11%
|
MDE, unidentified
|
England
|
Tab
|
white, Playboy, scored, .9 cm
|
No
|
0 mg
|
0%
|
MDE, unidentified
|
England
|
Tab
|
white, Playboy, scored, .9 cm
|
Yes
|
14 mg
|
5%
|
MDE, unidentified
|
England
|
Tab
|
yellow, Chicken, .9 cm
|
Yes
|
106 mg
|
35%
|
unidentified
|
England
|
Tab
|
white, Apple with a bite
|
Yes
|
131 mg
|
44%
|
caf, unidentified
|
England
|
Tab
|
clear, "Warm Speed"
|
No
|
0 mg
|
0%
|
caf
|
South Africa
|
Tab
|
yellow, scored, 1.2 cm
|
Yes
|
138 mg
|
23%
|
unidentified
|
What Else?
- dex = dextromethorphan
- caf = caffeine
- MDE = 3,4-methylenedioxyethylamphetamine
- phenyl = phenylpropanolamine
- eph = ephedrine / pseudoephedrine
- glyc = glyceryl guiaicolate
|