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MAPS Bulletin Spring 2012: Special Edition: Psychedelics and the Popular Arts
 
Resources > Psychedelic Research Papers
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This list contains a mix of original research and reviews of literature chiefly pertaining to psychedelic compounds (as LSD and psilocybin) and MDMA, with a strong focus on research in humans. Some reports describe findings from laboratory studies examining the effects of these drugs, while others recount historical use of psychedelics, particularly in psychiatry. A number of studies examine the use of these substances in therapeutic contexts, either as part of psychotherapy or as a pharmacotherapy. The list is not intended to be comprehensive but to present a broad survey of the currently available literature and to introduce readers to the nature and scope of the literature. Readers may wish to investigate the reference lists of any paper that interests them to locate further reports.

Except in one case, all reports can be found in PDF format within the MAPS Psychedelic Bibliography (http://www.maps.org/wwwpb). Citations are presented first, followed by a URL to a full-text article.

Updated by Ilsa Jerome (March, 2010)

contractList of Papers

1. Barbanoj MJ, Riba J, Clos S, Gimenez S, Grasa E, Romero S (2008) Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers. Psychopharmacology (Berl) 196: 315-326

http://www.maps.org/w3pb/new/2007/2007_Barbanoj_22958_1.pdf

2. Bedi G, Phan KL, Angstadt M, de Wit H (2009) Effects of MDMA on sociability and neural response to social threat and social reward. Psychopharmacology (Berl) 207: 73-83

http://www.maps.org/w3pb/new/2009/2009_Bedi_23084_2.pdf

3. Bouso JC, Doblin R, Farre M, Alcazar MA, Gomez-Jarabo G (2008) MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder. J Psychoactive Drugs 40: 225-236

http://www.maps.org/w3pb/new/2008/2008_Bouso_23071_1.pdf

4. Carter OL, Hasler F, Pettigrew JD, Wallis GM, Liu GB, Vollenweider FX (2007) Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans. Psychopharmacology (Berl) 195: 415-24

http://www.maps.org/w3pb/new/2007/2007_Carter_22935_2.pdf

5. Doblin R (1998) Dr. Leary's Concord Prison Experiment: a 34-year follow-up study. J Psychoactive Drugs 30: 419-426.

http://www.maps.org/research/1998_Doblin_ConcordPrisonFollow-up.pdf [HTML version].

Additional commentary is available in Ralph Metzner's Reflections on the Concord Prison Experiment and the Follow-Up Study.

6. Dumont GJ, Sweep FC, van der Steen R, Hermsen R, Donders AR, Touw DJ, van Gerven JM, Buitelaar JK, Verkes RJ (2009) Increased oxytocin concentrations and prosocial feelings in humans after ecstasy (3,4-methylenedioxymethamphetamine) administration. Soc Neurosci 4: 359-366

http://www.maps.org/w3pb/new/2009/2009_Dumont_23083_1.pdf

7. Dyck E (2005) Flashback: psychiatric experimentation with LSD in historical perspective. Can J Psychiatry 50: 381-388

http://www.maps.org/w3pb/new/2005/2005_Dyck_22866_1.pdf

8. Fantegrossi WE, Murnane KS, Reissig CJ (2008) The behavioral pharmacology of hallucinogens. Biochem Pharmacol 75: 17-33

http://www.maps.org/w3pb/new/2008/2008_Fantegrossi_22965_1.pdf

9. Gamma A, Buck A, Berthold T, Liechti ME, Vollenweider FX (2000) 3,4-Methylenedioxymethamphetamine (MDMA) modulates cortical and limbic brain activity as measured by [H(2)(15)O]-PET in healthy humans. Neuropsychopharmacology 23: 388-95

http://www.maps.org/w3pb/new/2000/2000_gamma_383_1.pdf

10. Geyer MA, Vollenweider FX (2008) Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci 29: 445-453.

http://www.maps.org/w3pb/new/2008/2008_Geyer_23106_1.pdf

11. Gouzoulis-Mayfrank E, Schreckenberger M, Sabri O, Arning C, Thelen B, Spitzer M, Kovar KA, Hermle L, Bull U, Sass H (1999) Neurometabolic effects of psilocybin, 3,4-methylenedioxyethylamphetamine (MDE) and d-methamphetamine in healthy volunteers. A double-blind, placebo-controlled PET study with [18F]FDG. Neuropsychopharmacology 20: 565-581

http://www.maps.org/w3pb/new/1999/1999_gouzoulis-mayfrank_412_1.pdf

12. Gouzoulis-Mayfrank E, Thelen B, Habermeyer E, Kunert HJ, Kovar KA, Lindenblatt H, Hermle L, Spitzer M, Sass H (1999) Psychopathological, neuroendocrine and autonomic effects of 3,4-methylenedioxyethylamphetamine (MDE), psilocybin and d-methamphetamine in healthy volunteers. Results of an experimental double-blind placebo-controlled study. Psychopharmacology (Berl) 142: 41-50

http://www.maps.org/w3pb/new/1999/1999_gouzoulis-mayfrank_6011_1.pdf

13. Griffiths R, Richards W, Johnson M, McCann U, Jesse R (2008) Mystical-type experiences occasioned by psilocybin mediate the attribution of personal meaning and spiritual significance 14 months later. J Psychopharmacol 22: 621-632

http://www.maps.org/w3pb/new/2008/2008_Griffiths_23042_2.pdf

14. Griffiths RR, Richards WA, McCann U, Jesse R (2006) Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance. Psychopharmacology (Berl) 187: 268-83; discussion 284-292

http://www.maps.org/w3pb/new/2006/2006_Griffiths_22780_2.pdf

15. Halpern JH, Pope HG, Jr. (1999) Do hallucinogens cause residual neuropsychological toxicity? Drug Alcohol Depend 53: 247-256

http://www.maps.org/w3pb/new/1999/1999_Halpern_23105_1.pdf

16. Halpern JH, Sherwood AR, Passie T, Blackwell KC, Ruttenber AJ (2008) Evidence of health and safety in American members of a religion who use a hallucinogenic sacrament. Med Sci Monit 14: SR15-22

http://www.maps.org/w3pb/new/2008/2008_Halpern_23045_1.pdf

17. Hasler F, Grimberg U, Benz MA, Huber T, Vollenweider FX (2004) Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study. Psychopharmacology (Berl) 172: 145-56

http://www.maps.org/w3pb/new/2004/2004_Hasler_20465_2.pdf

18. Johnson M, Richards W, Griffiths R (2008) Human hallucinogen research: guidelines for safety. J Psychopharmacol 22: 603-620

http://www.maps.org/w3pb/new/2008/2008_Johnson_23043_2.pdf

19. Krupitsky EM, Burakov AM, Dunaevsky IV, Romanova TN, Slavina TY, Grinenko AY (2007) Single versus repeated sessions of ketamine-assisted psychotherapy for people with heroin dependence. J Psychoactive Drugs 39: 13-9

http://www.maps.org/w3pb/new/2007/2007_Krupitsky_22899_1.pdf

20. Kurland AA, Grof, S., Pahnke, W. N., Goodman, L.E. (1973) Psychedelic Drug Assisted Psychotherapy. In Patients With Terminal Cancer. In: Goldberger IK, Malitz S, Kutscher AH (eds) Psychotheramacological Agents for the Terminally Ill and Bereaved 1973,. Columbia University Press, New York, NY, pp 86-133

http://www.maps.org/w3pb/new/1973/1973_kurland_2843_1.pdf

21. Liechti ME, Gamma A, Vollenweider FX (2001) Gender differences in the subjective effects of MDMA. Psychopharmacology (Berl) 154: 161-168

http://www.maps.org/w3pb/new/2001/2001_liechti_1098_1.pdf

22. Ludwig A, Levine J, Stark L, Lazar R (1969) A clinical study of LSD treatment in alcoholism. Am J Psychiatry 126: 59-69

http://www.maps.org/w3pb/new/1969/1969_ludwig_4840_1.pdf

22. Mangini M (1998) Treatment of alcoholism using psychedelic drugs: a review of the program of research. J Psychoactive Drugs 30: 381-418

http://www.maps.org/w3pb/new/1998/1998_Mangini_22901_1.pdf

23. Moreno FA, Wiegand CB, Taitano EK, Delgado PL (2006) Safety, tolerability and efficacy of psilocybin in 9 patients with Obsessive-Compulsive Disorder. J Clin Psychiatry 67: 1735-11740

http://www.maps.org/w3pb/new/2006/2006_Moreno_22868_1.pdf

24. Nichols DE (2004) Hallucinogens. Pharmacol Ther 101: 131-181

http://www.maps.org/w3pb/new/2004/2004_Nichols_22684_1.pdf

25. Passie T, Halpern JH, Stichtenoth DO, Emrich HM, Hintzen A (2008) The pharmacology of lysergic Acid diethylamide: a review. CNS Neurosci Ther 14: 295-314

http://www.maps.org/w3pb/new/2008/2008_Passie_23067_1.pdf

26. Passie T, Seifert J, Schneider U, Emrich HM (2002) The pharmacology of psilocybin.

Addict Biol 7: 357-64

http://www.maps.org/w3pb/new/2002/2002_Passie_22704_1.pdf

27. Riba J, Rodriguez-Fornells A, Barbanoj MJ (2002) Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively. Psychopharmacology (Berl) 165: 18-28

http://www.maps.org/w3pb/new/2002/2002_riba_6009_1.pdf

28, Sewell RA, Halpern JH, Pope HG, Jr. (2006) Response of cluster headache to psilocybin and LSD. Neurology 66: 1920-1922

http://www.maps.org/w3pb/new/2006/2006_Sewell_22779_1.pdf

29. Strassman RJ (1995) Hallucinogenic drugs in psychiatric research and treatment. Perspectives and prospects. The Journal of Nervous and Mental Disease 183: 127-138

http://www.maps.org/w3pb/new/1994/1994_Strassman_22714_1.pdf

30. Strassman RJ, Qualls C, Berg L (1996) Differential tolerance to biological and subjective effects of four closely spaced doses of N,N-dimethyltryptamine in humans. Biological Psychiatry 39: 784-795

http://www.maps.org/w3pb/new/1996/1996_Strassman_22710_1.pdf

31. Vollenweider FX, Leenders KL, Scharfetter C, Maguire P, Stadelmann O, Angst J (1997) Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis. Neuropsychopharmacology 16: 357-372

http://www.maps.org/w3pb/new/1997/1997_Vollenweider_22688_1.pdf

32. Vollenweider FX, Csomor PA, Knappe B, Geyer MA, Quednow BB (2007) The Effects of the Preferential 5-HT2A Agonist Psilocybin on Prepulse Inhibition of Startle in Healthy Human Volunteers Depend on Interstimulus Interval. Neuropsychopharmacology 32(9):1876-1887

http://www.maps.org/w3pb/new/2007/2007_Vollenweider_22893_2.pdf