An additional detail that has required rewriting the schedule of the double blind study is that we found a way to remove the bitterness. This eliminates our need to add quinine to duplicate the bitterness. The double blind study has not started yet.
In the dose establishment phase of this study we have tested subjects on 1/2 gram, 1 gram, 1.5 grams and 2.0 grams of dried and crumbled Salvia divinorum leaves. We had a hard time coming up with a placebo. Dried Comfrey leaves are a very close duplicate, but they lack the bitterness of Salvia divinorum We had a breakthrough in July when we found that if you wash dried and crumbled Salvia divinorum leaves in two changes of water‹2 full glasses of water per gram‹the bitterness of the Salvia is gone. The active ingredient Salvinorin-A is insoluble in water. When treated in this way you cannot tell Salvia divinorum from comfrey leaves prepared in the same way.
Almost everyone liked the 1.0 gram level for meditation. The half-gram dose was rarely detected by anyone. The 2.0 gram dose was too strong for meditation. Effects from the dried Salvia leaves soaked and washed in water and then placed under the tongue were as follows. The actual technique is to chew the leaves every five minutes or so and return them to under the tongue.
0.5 grams... half of the subjects noticed a slight effect... a clearer than normal mind that is free from distractions. The other half noticed nothing at all.
1.0 grams...everyone noticed it when they were in a quiet room with no distractions. Mind is clear and meditation is unusually easy with few distracting thoughts. This dose was only detected by anyone when they were trying to meditate. The effect made it easier tc oncentrate without thoughts... a definite plus for meditation. If they, however, listened to music or did some activity they could not notice any effect at all.
1.5 grams... half of subjects notice a trance like state beginning to happen. Effect is slight but it inhibits meditation for some.
2.0 grams produced a slightly trance like effect for some people with time distortion. Generally people found that level too strong for meditation. The effect was enjoyable however... a bit dream like and time seemed to slow down.
So those are the casual results from the dose establishment phase of the study. The next step will be the double blind study.