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Non-Human/In-Vitro Studies: Pharmacology (Definition) Jump to: 2003: January  |  February  |  March  |  April  |   May  |   June  |   July  |   2002: January  |  February  |  March  |  April  |  May  |  June  |  July  |  August  |  September  |  October  |  November  |  December   2001: October  |  November  |  December July 2003 Achat-Mendes C, Anderson KL, Itzhak Y. (2003) Methylphenidate and MDMA adolescent exposure in mice: long-lasting consequences on cocaine-induced reward and psychomotor stimulation in adulthood. Neuropharmacology 45:106-115. Banjaw MY, Mayerhofer A, Schmidt WJ. (2003) Anticataleptic activity of cathinone and MDMA (Ecstasy) upon acute and subchronic administration in rat. Synapse 49 232-238. >Lebsanft HB, Mayerhofer A, Kovar KA, Schmidt WJ. (2003) Is the Ecstasy-induced ipsilateral rotation in 6-hydroxydopamine unilaterally lesioned rats dopamine independent? J Neural Transm.110:707-718. Schmidt WJ, Mayerhofer A, Meyer A, Kovar KA (2002) Ecstasy counteracts catalepsy in rats, an anti-parkinsonian effect? Neurosci Lett 330: 251-254. Timar J, Gyarmati S, Szabo A, Furst S. (2003) Behavioural changes in rats treated with a neurotoxic dose regimen of dextrorotatory amphetamine derivatives. Behav Pharmacol 14:199-206. June 2003 Bogen IL, Haug KH, Myhre O, Fonnum F (2003) Short- and long-term effects of MDMA ("ecstasy") on synaptosomal and vesicular uptake of neurotransmitters in vitro and ex vivo. Neurochem Int 43: 393-400. Bowyer JD, Young JF, Slikker W, Itzhak Y, Mayorga AJ, Newport GD, Ali SF, Frederick DL, Paule MG (2003) Plasma levels of parent compound and metabolites after doses of either fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations. NeuroToxicology 24; 379-390 Setola V, Hufeisen SJ, Grande-Allen KJ, Vesely I, Glennon RA, Blough B, Rothman RB, Roth BL (2003) 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro. Mol Pharmacol 63: 1223-1229. May 2003 No updates available for May 2003 April 2003 Peng W, Simantov R (2003) Altered gene expression in frontal cortex and midbrain of 3,4- methylenedioxymethamphetamine (MDMA) treated mice: Differential regulation of GABA transporter subtypes. J Neurosci Res 72: 250-258. March 2003 No updates available for March 2003 February 2003 Arrue A, Ruiz-Ortega JA, Ugedo L, Giralt MT (2003) Short-term effects of 3,4-methylenedioximethamphetamine on noradrenergic activity in locus coeruleus and hippocampus of the rat. Neurosci Lett 337: 123-126 Fantegrossi WE, Godlewski T, Karabenick RL, Stephens JM, Ullrich T, Rice KC, Woods JH (2003) Pharmacological characterization of the effects of 3,4- methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology 1:1 January 2003 Peng W, Premkumar A, Mossner R, Fukuda M, Lesch KP, Simantov R (2002) Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA). Brain Res Mol Brain Res 108: 94-101. Sprague JE, Banks ML, Cook VJ, Mills, EM (2003) Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in the hyperthermia induced by 3,4-metbylenedioxymethamphetamine (MDMA, Ecstasy). JPET Fast Forward; Published On-line January 21, 2003. DOI:10.1124/jpet.102.044982 December 2002 Thiriet N, Ladenheim B, McCoy MT, Cadet JL (2002) Analysis of ecstasy (MDMA)-induced transcriptional responses in the rat cortex. Faseb J [The FASEB journal: official publication of the Federation of American Societies for Experimental Biology] 16: 1887-1894. Vandeputte C, Docherty JR (2002). Vascular actions of 3,4-methylenedioxymethamphetamine in alpha(2A/D)-adrenoceptor knockout mice. Eur J Pharmacol 457: 45-49 November 2002 No updates available for November 2002 October 2002 Cleary L, Buber R, Docherty J (2002) Effects of amphetamine derivatives and cathinone on noradrenaline-evoked contractions of rat right ventricle. Eur J Pharmacol 451: 303. September 2002 Murphy J, Flynn JJ, Cannon DM, Guiry PJ, McCormack P, Baird AW, McBean GJ, Keenan AK (2002). In vitro neuronal and vascular responses to 5-hydroxytryptamine: modulation by 4-methylthioamphetamine, 4-methylthiomethamphetamine and 3,4-methylenedioxymethamphetamine. Eur J Pharmacol 444: 61-67. Pompei P, Cavazzuti E, Martarelli D, Pediconi D, Arletti R, Lucas L, Massi M (2002). Preprotachykinin A gene expression after administration of 3,4- methylenedioxymethamphetamine (Ecstasy). Eur J Pharmacol 450; 245-251. August 2002 Gough B, Imam SY, Blough B, Slikker W, Ali SF (2002) Comparative effects of substituted amphetamines (PMA, MDMA and METH) on monoamines in rat caudate. Ann NY Acad Sci 965; 410-420 Ramamoorthy Y, Yu A, Suh N, Haining RL, Tyndale RF, Sellers EM (2002). Reduced (+/-)-3,4-methylenedioxymethamphetamine ("Ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochem Pharmacol 63: 2111-9. July 2002 No updates available for July 2002 June 2002 No updates available for June 2002 May 2002 No updates available for May 2002 April 2002 No updates available for April 2002 March 2002 Hansen JP, Riddle EL, Sandoval V, Brown JM, Gibbs JW, Hanson GR, Fleckenstein AE (2002). Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: Mechanisms and implications for neurotoxicity. J Pharmacol Exp Ther, 300: 1093-1100 February 2002 Fone KCF, Beckett SRC, Topham IA, Swettenham J, Ball M, Maddocks L (2002). Long-term changes in social interaction and reward following repeated MDMA administration to adolescent rats without accompanying serotonergic neurotoxicity. Psychopharmacology (Berl), 159: 437-444 Mechan AO, Esteban B, O'Shea E, Elliott, M, Colado I, Green AR (2002). The pharmacology of the acute hyperthermic response that follows the administration of 3,4-methylenedioxyemthamphetamine (MDMA, "ecstasy") to rats. Br J Pharmacol, 135: 170-180. Whitworth TL, Herndon LC, Quick MW (2002). Psychostimulants differentially regulate serotonin transporter expression in thalamocortical neurons. J Neurosci 22: RC192. January 2002 Forsling, ML, Fallon JK, Shah D, Tilbrook GS, Cowan DA, Kicman AT, Hutt AJ (2002). The effect of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') and its metabolites on neurohypophysial hormone release from the isolated rat hypothalamus. Br J Pharmacol 135: 649-656 Morley KC, Gallate JE, Hunt GE, Mallet PE, McGregor IS (2001). Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("Ecstasy"). Eur J Pharmacol 433: 91-9 December 2001 Biello SM, Dafters RI (2001). MDMA and fenfluramine alter the response of the circadian clock to a serotonin agonist in vitro. Brain Research, 920: 202-209 Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK (2001). Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60: 1181-8 Mortensen OV, Kristensen AS, Wiborg O (2001). Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants. J Neurochem 79: 237-47. November 2001 Connor, TJ, Connelly, DB, and Kelly, JP (2001). Methylenedioxymethamphetamine (MDMA, "Ecstasy") suppresses antigen-specific IgG2a and IFN-g production. Immunology Letters, 78; 67-73. Pedersen, NP and Blessing, WW (2001). Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy) in conscious rabbits. Journal of Neuroscience, 27: 8648-8654. October 2001 Ramamoorthy, Y, Tyndale, RF, and Sellers, EM (2001). Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics, 11: 477-487