After conducting studies of chronic amphetamine and cocaine exposure in rats and examining their brains, the author proposes that stimulants and MDMA damage axons in the fasciculus retroflexus (FR) of the habenula, while leaving cell bodies apparently undamaged. Axonal damage is proposed to occur through excitotoxic lesions, though evidence is namely drawn from studies of glucose metabolism during and after drug administration. Stages of rat behaviors seen during chronic amphetamine or cocaine administration (through time-release pellets) are compared with human trials wherein people were given amphetamine on an hourly basis. Near the end of chronic amphetamine exposure, rats exhibited the "wet dog shakes" and limb flicks more commonly associated with LSD, DOI, and other 5HT2A agonists. The same behavioral patterns were not seen after five daily injections of the same dose of amphetamine. While chronic amphetamine exposure produced degeneration of dopaminergic innervation of the caudate, both amphetamine and cocaine damaged habenula FR axons. Methamphetamine, MDMA and cathinone are also reported to produce axonal damage to the habenula FR after chronic administration. Because the FR serves as a major area providing feedback from the forebrain to the midbrain, and might serve in the regulation of midbrain reward from the forebrain, it is proposed that the neurotoxic effects of stimulant binges might also be related to effects seen in amphetamine dependence. Since the frequency of ecstasy binges is unknown but appears to be lower than for other stimulants, it is unclear how relevant this model would turn out to be when considering the effects of MDMA exposure in humans.