This paper is a very short overview of the effects of a variety of psychoactive drugs, most of them psychostimulants, in relation to seizures or epilepsy, with most data gathered from case studies or analyses of collections of case studies. MDMA is classified as a psychedelic drug. The authors cite a report from a Danish team indicating that seizures are the most common clinical complication in the CNS after ecstasy use. The findings from this report suggested that seizures associated with ecstasy use may be associated with severe hyponatremia. The neurotoxic actions of MDMA are described under the section dealing with "mechanisms of action," but no explanation is given as to how potential neurotoxicity after ecstasy is related to seizures after ecstasy use. No other potential mechanisms of action are presented. The information presented here concerning ecstasy and seizures is not sufficient for understanding the prevalence of seizures after ecstasy use outside of medical admissions, or the relationship between ecstasy use and epileptic activity. Seizure-related effects of other drugs, including cocaine, amphetamines, caffeine, cannabis and other psychedelic drugs are also addressed in this report.