In 1999, 10.1% (approximately 80) of 796 seniors attending a large New England college reported taking ecstasy at least once in their lives. Reported lifetime use of ecstasy had increased from reported lifetime use in 1989, when 4.1% of 369 undergraduates (approximately 15) reported using ecstasy. Overall drug use on this campus peaked in 1978 and has declined since then, while amount and pattern of alcohol consumption has remained stable over time. In 1999, undergraduates who used drugs were more likely to be sexually active and to have visited a psychiatrist. In previous years, no behaviors had been found that distinguished drug-using undergraduates from undergraduates who did not use drugs. These findings suggest that the characteristics of undergraduate drug users are shifting, perhaps as drug use becomes less a "normative" activity on campus.