295 Gay and bisexual men aged 18 or older, living in the San Francisco area, recruited through various means (at dance clubs, gyms and bars, through snowball sampling and advertisements) were asked about circuit party attendance, drug use and sexual behavior. Respondents were asked about attendance of circuit parties, drug use at circuit parties and during non-circuit party weekends, and instances of unprotected sex. While only 3% (approximately 8) of 260 respondents reported using ecstasy when not attending a circuit party or dance club, 80% (approx. 168) of 211 respondents reported using ecstasy at a distant circuit party and 75% of 265 respondents (approx. 199) had taken ecstasy at a local (San Francisco) circuit party. 50% of 275 respondents (approx. 138) used ecstasy at a dance club. Ecstasy proved more popular than cannabis or alcohol when at circuit parties. Ketamine, methamphetamine and "poppers' were also frequently used at circuit parties. Unprotected anal sex was more frequent at circuit parties, and significantly more prevalent at distant versus local circuit parties. However, a multivariate logistic regression model found that drug use in general, and specifically methamphetamine, amyl nitrate and sildenafil (Viagra) use was correlated with unprotected anal sex, and not ecstasy (or alcohol or cannabis) use. This paper is the second (compare with Mattison et al. 2001) to assess relationship between drug-use and unsafe sex in gay and bisexual men.