Most of the proposed study will take place at appropriate research facilities at McLean Hospital in Belmont, MA. McLean Hospital is a psychiatric facility and research hospital affiliated with Harvard Medical School. Pre-screening of prospective subjects and a medical examination performed one week after the second experimental session will be conducted by Dr. Shuster, the oncologist investigator, at the Department of Medical Oncology at the Lahey Clinic in Burlington, MA.

Staff at McLean Hospital will be capable of dealing with any medical or psychiatric emergencies that arrive during the course of either experimental sessions. As noted, Dr. Siegel will be present on grounds during each experimental session and will be reachable through on-call radio. There will be a crash cart available for treating hypertensive crises or other related events, and the investigators can call on staff to assist in treatment of medical emergencies. Diphenhydramine, injectable epinephrine, and other standard emergency drugs and equipment will be available in the treatment room if needed for countering an allergic reaction or other medical emergency. Available emergency medications include antihypertensive agents (such as nitroprusside and labetolol), pressor agents, anxiolytics, and intravenous fluids. In addition to these medications, the crash cart contains a defibrillator (with telemetry capability), an oxygen tank, a 12-lead electrocardiogram (ECG) device, a suction device, a pulse oxometer, an IVAC pump, and intubation equipment (including laryngoscope, and endotracheal tubes).

The hospital nearest McLean Hospital that has a medical emergency room and intensive care unit is Mt. Auburn Hospital, which is about four miles from McLean Hospital. It should take less than ten minutes to reach Mt. Auburn Hospital by ambulance.