Re: MAPS: Anybody up for some MDMA neurotoxicity tests on humans?

["Nicholas V. Cozzi, Ph.D." <nvcozzi@xxxxxxxxxxxxxxxx>]

At 09:03 PM 3/2/02 +0000, Little John wrote:

> According to the
> article, the serotonin re-uptake transporters are powered by a Ca++ gradient
> between the inside and outside of the cell membrane, with that gradient
> being actively maintained by the consumption of (typically) glucose.

Just to clarify, SERT-mediated uptake is coupled to the influx of Na+ and
Cl- and to the efflux of K+.  As you point out, the ionic gradients are
ultimately maintained by burning glucose.


Nicholas V. Cozzi, Ph.D.
Department of Pharmacology and Toxicology
Brody School of Medicine
East Carolina University
Greenville, NC  27858


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