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Re: MAPS: MDMA: other health-related effects?



At 06:43 9/01/99 -0800, Bob Greer wrote:
Actually, it was started by methamphetamine addicts (as well as beer drinkers).
 
Adolf Hitler was, in particular,  a heavy abuser of these on a daily basis beginning before he achieved elected office in Germany.   This is well documented, and was of considerable concern among the German officer corps at the time.  The drug was distributed within all levels of the German military and was freely available.
 
As the drug was invented in Japan, and retained a strong following there (among the military elite) until the end of WW II, the social effects of non-psychedelic and non-entactogenic drugs certainly deserve a careful reexamination.  (A joke in South East Asia, at this time, is that one can always tell when the Japanese tourists have been to the beach - by counting the hypodermic needles that litter the sand afterwards.  Shortly after World War II, large stocks of methamphetamine that were stockpiled by the Japanese government - to "energize" the citizens there in case of eventual invasion by foreigners, as well as for its' own use - were dumped into the lives of Japanese citizens.  Within a few more years, at least a third of the people at public beaches displayed serious needle tracks on their arms...)

There was also a lot of illicit manufacture of amphetamines in Japan in homes ("bathtub  speed"). In 1954 the Japanese Pharmacist Association estimated there were 1.5 million addicts of  Philopin, as it was called, mostly men between 16 and 25. A good book, a bit old but pretty sound in methodology, on amphetamine toxicity with respect to behaviour is Oriana Joseau Kalant, The Amphetamines: Toxicity and Addiction,  2nd Edition,  University of  Toronto Press, 1973 (first edition was published in 1966, well before the "war on drugs").  Both chronic consumption of amphetamines with and without ill effects are reported. Addiction, chronic use and toxicity from chronic use can all be separated in the population studied, i.e., one doesn't imply the other. The drugs considered were methamphetamine,  dexedrine, biamphetamine, phenmetrazine, methylphenidate and diethylpropion (the last three are not strictly amphetamines, but have similar effects clinically).

The most common toxic effect is a psychosis -- of the literature from outside Japan, of 242 reported cases , 83%, or 201 cases involved psychotic episodes "of a schizophrenic type" (I put that in quotes because schizophrenia is not a single condition). The psychoses resemble paranoid schizophrenia, very similar to cocaine induced psychoses, which were better known at the time.  The condition was clinically indistinguishable from paranoid schizophrenia. The symptoms ameliorate with withdrawal of the drug (except in some case that may indicate a pre-existing condition).

John

"Philosophy is an unusually ingenious attempt to think fallaciously"
                                                Bertrand Russell