Re: MAPS: QUERY: 5HT-degrading enzymes

[djscott@xxxxxxxxx]

Dear Andrew,
Iam impressed my your hypothesis, since you give no information as to your
finding belief. Would you please explain to me what you mean by the MAO
needing the uptake of 5-HT to deliver itself? Is this why  MAO sits inside
the vesicle? I mean, I always wondered why MAO was included within the
soma itself. Can you explain, and where do you get your understanding?
Hence, please tell me what MAO and Acitylcholindesterease have in common?
	Regards,
	Diann Scott



On Tue, 24 Nov 1998, Andrew Sewell wrote:

> On Sat, 21 Nov 1998, L. Granquist wrote:
> > What you read was actually vastly oversimplified.  5-HT *is* broken down by
> > monoamine oxidase A in the synapse.  I believe, however, that it is correct to
> > state that it is preferentially deactivated in the synapse by reuptake into
> > 5-HT neurons -- while ACh is preferentially deactived by the enzyme
> 
> I think you both might be partially right.  5-HT is broken down by MAO-A,
> but the MAO-A is located in vesicles in the axon terminus, so requires
> reuptake of the 5-HT from the synapse prior to degradation.
> Acetylcholinesterase, on the other hand, operates in the synapse itself.
> Still, I don't think that anyone could rule out an intrasynaptic serotonin
> degradation enzyme.
> 
> --Andrew Sewell, M.D.
> 
> 
> ------------------
> MAPS-Forum@xxxxxxxx, a member service of the Multidisciplinary Association
> for Psychedelic Studies (to become a member, see www.maps.org/memsub.html).
> To [un]subscribe, email the message text,
> [un]subscribe maps-forum youraddress to majordomo@xxxxxxxx
> 


------------------
MAPS-Forum@xxxxxxxx, a member service of the Multidisciplinary Association
for Psychedelic Studies (to become a member, see www.maps.org/memsub.html).
To [un]subscribe, email the message text,
[un]subscribe maps-forum youraddress to majordomo@xxxxxxxx