Re: MAPS: DIGEST: Re: Niacin and LSD

[gene johnson <gjohnson@xxxxxxx>]

Evan L Petee wrote:

> The mechanism may also be on the tryptophan to niacin pathway. The body
> can convert tryptophan to B-3 (niacin) so if one is niacin saturated, more
> tryptophan might go to serotonin (5-HT) production, which may be in a
> state of tweekedness, to use the medical term, due to the LSD.
>
> It would be interesting to compare naicin with naicinamide. Niacin in
> doses above 50 mg or so can cause a warm tingly flush (histamine?)

Actually prostaglandin D2 a vasodilator and part of the sleep onset cascade.
Histamine has been ruled out as the agent, much to the surprise of many!

Best,
Gene Johnson

> > From: Valerie Gremillion <valor@xxxxxxxxxxx>
> >
> > >>>I don't recall exactly where the information about niacin utilization for
> > >coming down from LSD came from.
> >
> > I believe the original research was done by Abran Hoffer in Canada, who
> > worked on niacin and schizophrenia as well as testing niacin and niacinamide
> > for bringing down trippers. i can't recall which research was which,
> > but they safely used doses of up to 6 grams.
> >       to bring down a bad-tripper, probably start at 1000-2000 mg and
> > supplement with additional if it hasn't worked. the person will markedly
> > calm down and eventually sleep.
> >
> > The mechanism for this (i hypothesize, i don't think it's been explicitly
> > published) is that niacinamide activates the 'valium' (benzodiazepine)
> > GABAergic receptor. it is low affinity but clearly sufficient at high
> > doses. it is not felt as a 'drug' however but as a natural state of more
> > calm and less anxiety.
> >
>
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