Re: MAPS: DIGEST: Re: Niacin and LSD

[Evan L Petee <epetee@xxxxxx>]

The mechanism may also be on the tryptophan to niacin pathway. The body
can convert tryptophan to B-3 (niacin) so if one is niacin saturated, more
tryptophan might go to serotonin (5-HT) production, which may be in a
state of tweekedness, to use the medical term, due to the LSD. 

It would be interesting to compare naicin with naicinamide. Niacin in
doses above 50 mg or so can cause a warm tingly flush (histamine?)which
some think unpleasant - an effect absent with niacinamide. One wonders,
however if that flush might be part of the benefit, physically or
psychologically.

Happy life,

-evan

On Wed, 9 Jun 1999 maps-forum@xxxxxxxx wrote:

> Contributions from Valerie Gremillion <valor@xxxxxxxxxxx>, Evan L Petee
> <epetee@xxxxxx>, John Lolis <DrBombay@xxxxxxxxxxx>, "Arturo R. Archiga
> Mantilla" <elefante@xxxxxxxxxxxxxxxx>, and "Karl Shikles"
> <k.shikles@xxxxxxxxxxxxxxx> 
> 
> -------------
> From: Valerie Gremillion <valor@xxxxxxxxxxx>
> 
> >>>I don't recall exactly where the information about niacin utilization for
> >coming down from LSD came from. 
> 
> I believe the original research was done by Abran Hoffer in Canada, who
> worked on niacin and schizophrenia as well as testing niacin and niacinamide
> for bringing down trippers. i can't recall which research was which, 
> but they safely used doses of up to 6 grams. 
> 	to bring down a bad-tripper, probably start at 1000-2000 mg and
> supplement with additional if it hasn't worked. the person will markedly
> calm down and eventually sleep. 
> 
> The mechanism for this (i hypothesize, i don't think it's been explicitly
> published) is that niacinamide activates the 'valium' (benzodiazepine) 
> GABAergic receptor. it is low affinity but clearly sufficient at high
> doses. it is not felt as a 'drug' however but as a natural state of more
> calm and less anxiety. 
> 


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