MAPS: Plasma MDMA Levels Nonlinear with Dose

[Bob Wallace <bobw@xxxxxxxxxxx>]

Gentlepeople,

Ran into an interesting report on a paper, 
(The Lancet, 353:503-504, 15-Feb-99); 
unfortunately my source (Forensic Drug 
Abuse Advisor) did not give title or authors. 

It basically says increases in MDMA dose 
cause much greater increases in peak 
plasma levels. There were not many subjects, 
but they were at least screened to make 
sure none were "slow metabolizers". 

Summary is best as a table:

Subjects  Dose  Cmax (peak plasma level)
        2      50          51
        8      75        126
        2    100        190
        8    125        229
        2    150        485
(Wish they had a couple more subjects at 150 mg...)

This could be an important factor in neurotoxicity 
studies. Also, anybody using MDMA could try 
to use the smallest dose that works for them, 
perhaps taking 1/2 or 2/3 of a pill first, and only 
boosting with the remainder if needed later. 


- Bob Wallace (just my opinion);  bobw@xxxxxxxxxxx

Mind Books offers publications about psychedelics; 
books@xxxxxxxxxxx, or http://www.promind.com

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