The overarching goal of an MDMA-assisted session in this patient population is to reduce the symptoms of PTSD and to improve overall functioning and quality of life. This is accomplished through gaining new perspectives about life experiences, and clearing emotional and somatic blocks resulting from past trauma. This is accomplished through confronting trauma-related memories, thoughts, and feelings within a designated "safe space" provided by the therapeutic set and setting and the effects of the MDMA.

The MDMA-assisted treatment sessions are discussed below in three steps. As the therapists prepare the patient for ingesting the medication, they take time to talk with the patient and familiarize him/her with the MDMA experience. The next step involves working with the acute and sub-acute effects of the medication and the final step addresses the therapists' role throughout the treatment session.